Dr Miao Zhang

Associate Professor

Pharmacy

School of Pharmacy

Expertise: Ion Channels; Structural Biology; Electrophysiology; Drug Discovery; Movement Disorders

Email: zhang@chapman.edu

Education:: Hebei Medical University, Bachelor of Science
Hebei Medical University, Master of Science
Kyoto University, Ph.D.

Recent Creative, Scholarly Work and Publications: Orfali R, Alwatban AZ, Orfali RS, Lau L, Chea N, Alotaibi AM, Nam YW, Zhang M*. Oxidative stress and ion channels in neurodegenerative diseases. Frontier in Physiology. 2024 Jan 29;15:1320086; Nam YW, Rahman MA, Yang G, Orfali R, Cui M *, Zhang, M *. Loss-of-function KCa2.2 mutations abolish channel activity. American Journal of Physiology Cell Physiology. 2023 Mar 1;324(3):C658-C664.; Orfali R, Alfaiz Ali, Rahman MA, Lau L, Nam YW*, Zhang M*. KCa2 and KCa3.1 Channels in the Airways: A New Therapeutic Target. Biomedicines. 2023, 11(7), 1780.; Rahman MA, Orfali R, Dave N, Lam E, Naguib N, Nam YW*, Zhang M*. KCa2.2 (KCNN2): A physiologically and therapeutically important potassium channel. J Neuroscience Research. 2023 Jul 19;. doi: 10.1002/jnr.25233.; Zhang M, Wulff H. Chapter 8: Small-Conductance Calcium-Activated Potassium (SK) Channels. Textbook of Ion Channels Volume II Properties, Function, and Pharmacology of the Superfamilies. CRC Press. Taylor & Francis Group. 2023; Rahman MA, Chandrashekar DV, Nam YW, Syed B, Salehi D, Aliabadi MA, Zhang M*, Mehvar R*. Development and validation of a UPLC-MS/MS method to investigate the plasma pharmacokinetics of a KCa2.2/KCa2.3 positive allosteric modulator in mice. Rapid Communications in Mass Spectrometry. 2023 May 15;e9537.; Nam YW, Pala R, El-Sayed NS, Larin-Henriquez D, Amirrad F, Yang G, Rahman MA, Orfali R, Downey M, Parang K, Nauli SM *, Zhang, M *. Subtype-selective positive modulation of KCa2.3 channels increases cilia length. ACS Chemical Biology. 2022 Aug 19;17(8):2344-2354.; Nam YW, Pala R, El-Sayed NS, Larin-Henriquez D, Amirrad F, Yang G, Rahman MA, Orfali R, Downey M, Parang K, Nauli SM *, Zhang, M *. Subtype-selective positive modulation of KCa2.3 channels increases cilia length. ACS Chemical Biology. 2022 Aug 19;17(8):2344-2354.; Orfali R, Nam YW, Nguyen HM, Rahman MA, Yang G, Cui M, Wulff H, Zhang M *. Channelopathy-causing mutations in the S45A/S45B and HA/HB helices of KCa2.3 and KCa3.1 channels alter their apparent Ca2+ sensitivity. Cell Calcium. 2022 Jan 8;102:102538.; El-Sayed NS, Nam YW, Egorova PA, Nguyen HM, Orfali R, Rahman MA, Yang G, Wulff H, Bezprozvanny I *, Parang K *, Zhang M *. Structure-activity relationship study of subtype-selective positive modulators of KCa2 channels. Journal of Medicinal Chemistry. 2022 Jan 13;65(1):303-322.; Nam YW, Downey M, Rahman MA, Cui M, Zhang M *. Channelopathy of small- and intermediate-conductance Ca2+-activated K+ channels. Acta Pharmacologica Sinica. 2022 Jun 17;; Nam YW, Meng Cui, El-Sayed NS, Orfali R, Nguyen M, Yang G, Rahman MA, Lee J, Zhang M *. Subtype-selective positive modulation of KCa2 channels depends on the HA/HB helices. British Journal of Pharmacology. 2022 Feb;179(3):460-472.; Nam YW, Kong D, Wang D, Orfali R, Sherpa RT, Totonchy J, Nauli SM, Zhang M *. Differential regulation of SK channel subtypes by phosphorylation. Cell Calcium. 2021 Mar;94:102346.; Nam YW, Cui M, Orfali R, Viegas A, Nguyen M, Mohammed EHM, Zoghebi KA, Rahighi S, Parang K, Zhang M *. Hydrophobic interactions between the HA helix and S4-S5 linker modulate apparent Ca2+ sensitivity of SK2 channels. Acta Physiol (Oxf). 2021 Jan;231(1):e13552.; Alfuraih S, Barbarino A, Ross C, Shamloo K, Zhang M, Sharma A. Effect of high glucose on ocular surface epithelial cell barrier and tight junction proteins. Investigative Ophthalmology & Visual Science. 2020 Sep;61(3).; Nam YW, Baskoylu SN, Gazgalis D, Orfali R, Cui M, Hart AC, Zhang M*. A V-to-F substitution in SK2 channels causes Ca 2+ hypersensitivity and improves locomotion in a C. elegans ALS model. Scientific Reports. 2018 Jul 16;8(1):10749.; Nam YW, Orfali R, Liu T, Yu K, Cui M, Wulff H, Zhang M*. Structural insights into the potency of SK channel positive modulators. Scientific Reports. 2017 Dec 7;7(1):17178.; Brown BM, Shim H, Zhang M, Yarov-Yarovoy, V, Wulff H. Structural determinants for the selectivity of the positive KCa3.1 gating modulator 5- methylnaphtho[2,1-d]oxazol-2-amine (SKA-121). Molecular Pharmacology. July 31, 2017, mol.117.109421.; Zhang M*, Meng XY, Zhang JF, Cui M, Logothetis DE*. Molecular overlap in the regulation of SK channels by small molecules and phosphoinositides. Science Advances. 2015 Jul e1500008.; Logothetis DE, Petrou VI, Zhang M, Mahajan R, Meng XY, Adney SK, Cui M, Baki, L. Phosphoinositide control of membrane protein function: a frontier led by studies on ion channels. Annu Rev Physiol. 2015; 77:10.1-10.24.; Cui M, Qin G, Yu K, Bowers MS, Zhang M. Targeting the Small- and Intermediate-Conductance Ca2+-Activated Potassium Channels: The Drug-Binding Pocket at the Channel/Calmodulin Interface. Neurosignals. 2014; 22:65-78.; Zhang M, Meng XY, Cui M, Pascal JM, Logothetis DE, Zhang JF. Selective phosphorylation modulates the PIP2 sensitivity of the CaM-SK channel complex. Nature Chemical Biology. 2014 Sep 10(9):753-9.; Mahajan R, Ha J, Zhang M, Kawano T, Kozasa T, Logothetis DE. A Computational Model Reveals the Action of Gß at an Inter-Subunit Cleft to Activate GIRK1 Channels. Science Signaling. 2013 Aug 13; 6 ra69. (Selected as Cover for the issue); Zhang M, Pascal JM, Zhang JF. Unstructured to structured transition of an intrinsically disordered protein fragment in coupling Ca2+-sensing and SK channel activation. Proc Natl Acad Sci USA. 2013 Mar 19;110(12):4828-33.; Zhang M, Pascal JM, Schumann M, Armens RS, Zhang JF. Identification of the functional binding pocket for compounds targeting small-conductance Ca2+-activated potassium channels. Nature Communications. 2012 Aug 28;3:1021.; Zhang M, Abrams C, Wang L, Gizzi A, He L, Lin R, Chen Y, Loll PJ, Pascal JM, Zhang JF. Structural basis for calmodulin as a dynamic calcium sensor. Structure (Cell Press). 2012 May 9;20(5):911-23.

Dr Miao Zhang

Recent Creative, Scholarly Work and Publications

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